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Multi-omics Study of Planobispora rosea

American Society for Microbiology
56K subscribers
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Planobispora rosea is a genetically intractable bacterium used for the production of GE2270A on an industrial scale. GE2270A is a potent thiopeptide antibiotic currently used as a precursor for the synthesis of two compounds under clinical studies for the treatment of Clostridium difficile infection and acne. Here, we present the very first systematic multi-omics investigation of this important bacterium, which provides a much-needed detailed picture of the dynamics of metabolism of P. rosea while producing GE2270A. DOI: https://doi.org/10.1128/mSystems.0034... Title: Multi-omics Study of Planobispora rosea, Producer of the Thiopeptide Antibiotic GE2270A Authors: Francesco Del Carratore (https://orcid.org/0000-0003-1647-7818) , Marianna Iorio, Mercedes Pérez-Bonilla, Kamila Schmidt, Rosario Pérez-Redondo, Margherita Sosio, Sandy J. Macdonald, Ivan S. Gyulev, Areti Tsigkinopoulou, Gavin H. Thomas, Olga Genilloud, Antonio Rodríguez-García, Stefano Donadio, Rainer Breitling, Eriko Takano (https://orcid.org/0000-0002-6791-3256) Editor: Matthew F. Traxler Published in mSystems® on 22 June 2021 ...more
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Multi-omics Study of Planobispora rosea
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614Views
2021Jun 28
Planobispora rosea is a genetically intractable bacterium used for the production of GE2270A on an industrial scale. GE2270A is a potent thiopeptide antibiotic currently used as a precursor for the synthesis of two compounds under clinical studies for the treatment of Clostridium difficile infection and acne. Here, we present the very first systematic multi-omics investigation of this important bacterium, which provides a much-needed detailed picture of the dynamics of metabolism of P. rosea while producing GE2270A. DOI: https://doi.org/10.1128/mSystems.0034... Title: Multi-omics Study of Planobispora rosea, Producer of the Thiopeptide Antibiotic GE2270A Authors: Francesco Del Carratore (https://orcid.org/0000-0003-1647-7818) , Marianna Iorio, Mercedes Pérez-Bonilla, Kamila Schmidt, Rosario Pérez-Redondo, Margherita Sosio, Sandy J. Macdonald, Ivan S. Gyulev, Areti Tsigkinopoulou, Gavin H. Thomas, Olga Genilloud, Antonio Rodríguez-García, Stefano Donadio, Rainer Breitling, Eriko Takano (https://orcid.org/0000-0002-6791-3256) Editor: Matthew F. Traxler Published in mSystems® on 22 June 2021

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American Society for Microbiology

56K subscribers