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Antibacterial nanofibers for wound repair - Video abstract [ID 380786]

Dove Medical Press
35.7K subscribers
452 views 2 years ago
Video abstract of an original research "Powerful antibacterial nanofibers for accelerating wound repair after multi-drug resistant MRSA wound infection" published in the open access International Journal of Nanomedicine by Lei Ran, Shi-Ya Peng, Wei Wang et al. Purpose: Developing the ideal drug or dressing is a serious challenge to controlling the occurrence of antibacterial infection during wound healing. Thus, it is important to prepare novel nanofibers for a wound dressing that can control bacterial infections. In our study, the novel self-assembled nanofibers of benzalkonium bromide with bioactive peptide materials of IKVAV and RGD were designed and fabricated. Methods: Different drug concentration effects of encapsulation efficacy, swelling ratio and strength were determined. Its release profile in simulated wound fluid and its cytotoxicity were studied in vitro. Importantly, the antibacterial efficacy, inhibition of biofilm formation …...more
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Antibacterial nanofibers for wound repair - Video abstract [ID 380786]
8Likes
452Views
2022Sep 20
Video abstract of an original research "Powerful antibacterial nanofibers for accelerating wound repair after multi-drug resistant MRSA wound infection" published in the open access International Journal of Nanomedicine by Lei Ran, Shi-Ya Peng, Wei Wang et al. Purpose: Developing the ideal drug or dressing is a serious challenge to controlling the occurrence of antibacterial infection during wound healing. Thus, it is important to prepare novel nanofibers for a wound dressing that can control bacterial infections. In our study, the novel self-assembled nanofibers of benzalkonium bromide with bioactive peptide materials of IKVAV and RGD were designed and fabricated. Methods: Different drug concentration effects of encapsulation efficacy, swelling ratio and strength were determined. Its release profile in simulated wound fluid and its cytotoxicity were studied in vitro. Importantly, the antibacterial efficacy, inhibition of biofilm formation effect and wound healing against MRSA infections in vitro and in vivo were performed after observing the tissue toxicity in vivo. Results: It was found that the optimized drug load (0.8%) was affected by the encapsulation efficacy, swelling ratio, and strength. In addition, the novel nanofibers with average diameter (222.0 nm) and stabile zeta potential (− 11.2 mV) have good morphology and characteristics. It has a delayed released profile in the simulated wound fluid and good biocompatibility with L929 cells and most tissues. Importantly, the nanofibers were shown to improve antibacterial efficacy, inhibit biofilm formation, and lead to accelerated wound healing following infection with methicillin-resistant Staphylococcus aureus. Conclusion: These data suggest that novel nanofibers could effectively shorten the wound-healing time by inhibiting biofilm formation, which make it promising candidates for treatment of MRSA-induced wound infections. Rad the full paper here: https://www.dovepress.com/in-vitro-an...

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Dove Medical Press

35.7K subscribers